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USB CDC exemple dont work in debug

Hi all
I'm working on a STM32F303CC very simple board.
I need to use a USB Virtual COM (CDC) for a MtoM data transfer with a Windows PC
I set up BSP with STMCubeMx and compiling/debuging with Keil V5 with an STlink V2 in SWD mode
board and microcontrolers are powered by USB
all look's working great when I make a hard reset (just fresh power up) but if I try to make a soft reset like when entering in debug despite Virtual Com Port is well enumerated on windows side it could not open com port and no Usb transmit can be done on target side becase of Usb Device descriptor not defined in Usb Midle ware
does anyone faced the same issue or somthing similare ?
thank's for any help