MHU v2.1 - R2NR interrupt

MHU v2.1 is integrated as part of Arm Corstone SSE-700 Subsystem and serve as the mailbox unit for the system.

it contains several types of interrupt (3 towards the sender and up to 33 towards to receiver).

i'm trying to understand what shall happen to cause R2NR interrupt to rise.

Documentations mention that it rises when  "ACC_RDY goes LOW",

however, Documentations doesn't say what causes ACC_RDY to go low.

any idea?