Streamline debug and symptom pattern

I've used streamline for debugging performance recently. The workflow seems fine to me: use performance report; analyze GPU counters and use graphics analyzer in case GPU bound; analyze CPU counters and use call paths/functions in case CPU bound

The analyze part is kind of a trouble to me. There are a lot of counters so I often don't know where to start and how to detect problem from there. I watched some use cases in the document but I think I want to hear out more of your cases about how you quickly detect the performance problems and are there anything like symptom pattern?

Thanks in advance for all of your helps