aarch64-none-linux-gnu-gdb ( version 12.3) cannot run, with python errors

aarch64-none-linux-gnu-gdb

Could not find platform independent libraries <prefix>
Could not find platform dependent libraries <exec_prefix>
Consider setting $PYTHONHOME to <prefix>[:<exec_prefix>]
Python path configuration:
PYTHONHOME = (not set)
PYTHONPATH = (not set)
program name = '/usr/local/bld-tools/bld-tools-virtual-env/bin/python'
isolated = 0
environment = 1
user site = 1
import site = 1
sys._base_executable = '/usr/local/bld-tools/bld-tools-virtual-env/bin/python'
sys.base_prefix = '/usr'
sys.base_exec_prefix = '/usr'
sys.executable = '/usr/local/bld-tools/bld-tools-virtual-env/bin/python'
sys.prefix = '/usr'
sys.exec_prefix = '/usr'
sys.path = [
'/usr/lib/python38.zip',
'/usr/lib/python3.8',
'/usr/lib/lib-dynload',
]
Fatal Python error: init_fs_encoding: failed to get the Python codec of the filesystem encoding
Python runtime state: core initialized
ModuleNotFoundError: No module named 'encodings'

Current thread 0x00007f1c07ce7c00 (most recent call first):
<no Python frame>

export  PYTHONPATH=/usr/bin/:~/.local/lib/python3.10/:/usr/lib/python3.10/

export PYTHONHOME=/usr/bin/

Fatal Python error: init_sys_streams: can't initialize sys standard streams
Python runtime state: core initialized
Traceback (most recent call last):
File "/usr/lib/python3.10/io.py", line 54, in <module>
ImportError: cannot import name 'text_encoding' from 'io' (unknown location)